epihet for intra-tumoral epigenetic heterogeneity analysis and visualization

epihet for intra-tumoral epigenetic heterogeneity analysis and visualization

Blog Article

Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is linked to the deregulation of transcription.However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity.We developed an R/Bioconductor package, epihet, to Wart and Corn Removers calculate the intra-tumoral epigenetic heterogeneity and to perform differential epigenetic heterogeneity analysis.Furthermore, epihet can implement a biological network analysis workflow for transforming cancer-specific differential epigenetic heterogeneity loci into cancer-related biological function and clinical biomarkers.Finally, we demonstrated epihet utility on acute myeloid leukemia.

We found statistically Bosch Serie 4 DWK095G60B 90 cm Angled Chimney Cooker Hood - Black - C Rated significant differential epigenetic heterogeneity (DEH) loci compared to normal controls and constructed co-epigenetic heterogeneity network and modules.epihet is available at https://bioconductor.org/packages/release/bioc/html/epihet.html.